AD is accounting for 60–80% of the total number of dementia, characterized by extracellular fibrillar amyloid β (Aβ), especially long form 42 amino acids of Aβ (Aβ42) deposits (amyloid plaques), intracellular neurofibrillary tangles (NFT, phosphate-tau related), and neuronal as well as axonal degeneration in the brain [4–6]. Here, MAPT is linked to Alzheimer disease.