Using a redox proteomics approach, several specific targets of protein oxidation such as peptidyl prolyl cis-trans isomerase and ubiquitin carboxyl terminal hydrolase 1 have been identified in the hippocampus but not in the cerebellum in AD [17], indicating that oxidatively modified proteins were consistent with biochemical or pathological alterations in AD. Here, USP1 is linked to Alzheimer disease.