HPV-coinfected individuals were at a less advanced stage of HIV disease than HPV-negative ones, as documented by the shorter duration of HIV infection (median, IQR: 68 months, 29–169 versus 120 months, 39–181; P = 0.028) and higher nadir CD4 cell counts (median, IQR: 271 cells/mmc, 157–392 in HPV positive versus 209 cells/mmc, 139–287; P = 0.028). This evidence concerns the gene CD4 and HIV infectious disease.