EGFR and adenocarcinoma: On the other hand, gefitinib, one of the epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), is effective, especially in patients with adenocarcinomas who are women, never-smokers and Asian [1].Recently, several studies have shown that NSCLC tumors were highly responsive to the EGFR-TKIs, gefitinib and erlotinib, in patients with somatic mutations of the EGFR gene, such as a point mutation at exon 21 (L858R) or a base pair-deletion at exon 19 (del746_A750) [2–4].