However, in 2011, Kalirai et al were able to demonstrate the expression of SOX-10, as a primitive migratory neural crest marker, along with HMB-45 in human uveal melanoma cell lines from both the primary tumour (Mel270) and a cell line derived from a liver metastasis of the same patient (Omm2.5). The gene discussed is PMEL; the disease is uveal melanoma.