Of the 15 tumors subject to glycolytic metabolic profiling, nine patients were identified with tumor and/or BCSC mutations in the catalytic subunit encoding the PI3K enzyme PIK3CA. Examination of whether the PI3K/AKT mutations correlated with changes in tumor or BCSC metabolic gene expression observed in the HypoxyGluMet array did not identify any predictive differences (data not shown). This evidence concerns the gene AKT1 and neoplasm.