Although the CD49flowCD24low BCSC subpopulation exhibited nearly twofold increased expression of HIF-1α (p = 0.02) compared with the tumor of origin, with corresponding increases in expression of downstream HIF-1α-dependent genes (LOX, VEGFA), we did not observe significant differences in the expression of HIF-1α-dependent glucose metabolism genes (Fig 4h). Here, HIF1A is linked to neoplasm.