After treatment with 5-Aza and pre-differentiation in vitro, we tested the ability of the hDPSCs and hAFSCs to restore dystrophin expression and contribute to the amelioration of the pathological features associated with dystrophic skeletal muscle when intramuscularly injected into mdx/SCID mice, an immune-compromised animal model of DMD. This evidence concerns the gene DMD and Duchenne muscular dystrophy.