CAV1 and adenocarcinoma: With a proportional hazard model controlling for age at diagnosis (HR = 1.061, 95% CI 1.022 to 1.101, Wald test p = 0.002) and the adenocarcinoma histotype (HR = 0.521, 95% CI 0.301 to 0.901, Wald test p = 0.020), Cav1 expression in the metastasis (HR = 2.359, 95% CI 1.309 to 4.251, Wald test p = 0.004) was associated with an increased risk of death, demonstrating its value as an independent predictor (Table 5a).