Vascular injury has an impact in other connective tissue diseases (CTDs) and is particularly evident in mixed connective tissue disease (MCTD), a chronic immune-mediated disease associated with anti-U1-RNP autoantibodies and clinical features from SSc, systemic lupus erythematosus (SLE) and polymyositis (PM). This evidence concerns the gene SNRNP70 and systemic lupus erythematosus.