However, when including patients that developed PAH within the first 2 years after blood sampling we found for each one SD increase in endostatin levels the odds of developing PAH increased with 70 % (OR = 1.7, 95 % CI: 1.2–2.4, P = .005) (see Additional file 3). The gene discussed is COL18A1; the disease is pulmonary arterial hypertension.