Due to the lack of the autocrine activation of NF-κB and STAT-3 in the S100A9-expressing oral cancer cells and a crosstalk requirement for IL-6 production, we tested if S100A9-bearing CM from oral cancer TW-2.6 cells would have any effect on the IL-6 production in monocytic U937 cells by using Western blot. The gene discussed is S100A9; the disease is lip and oral cavity carcinoma.