CXCL8 and Decreased total neutrophil count: Serum levels of IL-8, IL-6, IL-10 and C-reactive protein (CRP) could be used as differentiation markers for high and low risk pediatric oncology patients with neutropenia [26] whereas in adult oncology patients, serum concentrations of CRP, IL-6, IL-8 and sIL-2R were elevated in the afebrile neutropenic period [27].