The 9 patients with a skin GvHD stage II and III, developed significant increases of IL-6 (P = 0.0010), sIL-2R (P = 0.0049) and TNF-α (P = 0.0020) in the serum, whereas IL-8, IL-10 and IL-1ß did not significantly change. This evidence concerns the gene IL1B and neoplasm.