RELB, central to non-canonical NF-κB activation, may be an obvious candidate and has been shown to be activated by BAFF-R, lymphotoxin-β and CD40 ligand, all of which have been shown to activate B cells and contribute to lymphomagenesis.43, 44, 45RELB can also heterodimerize with p50 upon canonical NF-κB activation, which has a significant role in lymphoma.46 Here, CD40LG is linked to lymphoma.