In an analysis of 180 DLBCLs, Monti and colleagues used high-density SNP arrays to identify CNAs in DLBCL and reported that alteration of the p53 pathway and cell cycle genes predicted overall survival.40 Patients with ‘complex tumors' or those who had multiple alterations in p53/cell cycle genes had decreased overall survival. This evidence concerns the gene TP53 and diffuse large B-cell lymphoma.