Germinal center B-cell (GCB)-DLBCL is characterized by frequent amplifications in REL and BCL2 translocations.35, 36 Consistent with these studies, we also found that the BCL2/IGH fusion was restricted to GCB-DLBCL (Supplementary Table 1), whereas gains in REL trended toward GCB-DLBCL (70% of REL gains were in GCB cases, data not shown). The gene discussed is REL; the disease is diffuse large B-cell lymphoma.