Recent studies have suggested an important prognostic role for NOTCH1 and SF3B1 in CLL.15, 38, 39 However, no study has performed a multivariate analysis including traditional clinical and laboratory markers, flow cytometry factors, IgVH status and, at least, the presence of ATM, TP53, NOTCH1 and SF3B1 variants. This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.