SF3B1 and B-cell chronic lymphocytic leukemia: Recent studies have suggested an important prognostic role for NOTCH1 and SF3B1 in CLL.15, 38, 39 However, no study has performed a multivariate analysis including traditional clinical and laboratory markers, flow cytometry factors, IgVH status and, at least, the presence of ATM, TP53, NOTCH1 and SF3B1 variants.