Our results also highlight the possibility of radiosensitizing NPC with reduced miR-23a by inhibiting IL-8/Stat3 signaling, given that increased level of IL-8 and phospho-Stat3 was seen in the radioresistant NPCs with reduced miR-23a, and IL-8 knockdown and Stat3 inhibitor Stattic treatment significantly abrogated NPC cell radioresistance. Here, CXCL8 is linked to nasopharyngeal carcinoma.