For instance, a similar approach taken on the host immune system-level, led to the discovery that naturally-occurring Tlr4 mutation in C3H/HeJ mice caused failure of ICD/AVE – an observation that paved way for eventual characterization of a subset of breast cancer patients possessing TLR4 SNP polymorphism (+896A/G → Asp299Gly) that associated with poor prognosis under treatment with ICD inducers [50, 51]. Here, TLR4 is linked to breast carcinoma.