As well, Annexin V-FITC/PI staining revealed an increased apoptosis of AML cells while increasing PARP-1 inhibition (Fig. 2A, 2B), which was further confirmed by lower levels of anti-apoptotic proteins Bcl-2 and Bcl-xL (Fig. 2C, 2D). Here, ANXA5 is linked to acute myeloid leukemia.