Thus, we are currently in the long-term process of utilizing an established genetically engineered mouse model (GEMM) of PDA – KrasLSL-G12D/+; Trp53LSL-R172H/+; Cre (KPC) – as a background to manipulate pancreas-specific HuR expression (Sawicki et al., unpublished) [71]. The gene discussed is ELAVL1; the disease is Patent ductus arteriosus.