SPRY2 and lung adenocarcinoma: Genes significantly upregulated upon STAT3 knockdown were SPRY2, TIMP3, PTEN and CDKN1A. Intriguingly, we also found an inverse correlation of miR-21 with SPRY2 and TIMP3 (Figure 9E) in gene expression profiles of lung adenocarcinoma samples from TCGA, emphasizing the importance of studying STAT3-miR-21 interactions in BM.