Finally, Lon overexpression correlates with cancer cell aggressiveness, and indeed Lon is up-regulated in several cancer cells, including RKO colon carcinoma, HepG2 hepatocarcinoma, large cell lymphoma cell lines, Granta mantle cell lymphoma cell lines, and ex vivo specimens obtained from colon carcinoma and bladder cancer [3, 11, 13–16]. This evidence concerns the gene LONP1 and cancer.