Therefore, with specific functions required for de novo transcription initiation but not reinitiation, the canonical TFIID complex has the potential to be even more selective than TFIIH, another component of the Pol II core transcription machinery that was recently found to be a promising target for cancer therapy development (Titov et al., 2011; Chipumuro et al., 2014; Kwiatkowski et al., 2014). The gene discussed is TBP; the disease is cancer.