AZD5582 induced the cleavage of caspase-3, resulting in active caspase-3, but only in the BxPC-3 & PanC-1 cell lines which were sensitive to AZD5582 (Figure 1B, lower panel), indicating that pancreatic cancer cells have differential sensitivity to AZD5582. This evidence concerns the gene CASP3 and pancreatic neoplasm.