Consistent with these results, cIAP1 levels in XIAP-knockout, or XIAP levels in cIAP1-knockout MEFs was decreased in response to AZD5582, suggesting that the inhibition of both XIAP and cIAP1 is required to kill these AZD5582-sensitive pancreatic cancer cells. The gene discussed is BIRC2; the disease is familial pancreatic carcinoma.