IFNG and rheumatoid arthritis: Findings in a recent study suggested that Treg cell suppressive function (defined by suppression of T cell proliferation and IFNγ production) was defective in patients with early, active RA who had not yet received therapy (treatment‐naive), whereas Treg cell suppressive function was not defective in patients with chronic RA who had been exposed to methotrexate (MTX), although the group numbers were small (n = 4 per study group) 47.