MYC and lymphoma: For example, the cluster 17–92 is located at 13q31, a region commonly amplified in lymphomas13; miR-143 and miR-145 are located at 5q33, which is frequently deleted in myelodisplastic syndromes, and miR-142 is located 50 nucleotides from the t(8;17) breakpoint region, which involves chromosome 17 and MYC. This translocation juxtaposes the MYC gene to the miR-142 promoter, and overexpresses an abnormal MYC that is associated with lymphomas and pro-lymphocytic leukemia14.