AR/miR-190a/YB-1 signaling forms an auto-regulatory negative feedback loop in prostate cancer, where androgen/AR inhibits miR-190a expression through direct binding to the ARE in the miR-190a promoter, and miR-190a inhibits AR expression and activity through binding 3′-UTR of YB-1 gene. The gene discussed is YBX1; the disease is Familial prostate cancer.