FADD and autoimmune lymphoproliferative syndrome: This stoichiometry is in agreement with data by Esposito et al.,43 who also reported a ratio of 5 × CD95:5 × FADD together with some 6 × CD95:5 × FADD and 7 × CD95:5 × FADD ratios, but not the 4 × CD95:4 × FADD suggested by Scott et al. Disparities between these models could be explained by the different conditions used for protein crystallisation; however, the models proposed by Wang et al. and Esposito et al. are supported by the fact that they account for mutations frequently seen in autoimmune lymphoproliferative syndrome.