CASP8 and cancer: Despite this, expression of both procaspase-8 and procaspase-10 is frequently downregulated in cancer.26, 27, 28 Interestingly, the genes encoding procaspase-8 (Casp8), procaspase-10 and FLIP (CFLAR) are present at the same loci (2q33-q34) and clearly evolved via gene duplication events.