NFKB1 and cancer: They promote caspase activation and elicit an apoptotic response by binding to and inhibiting IAPs, which are overexpressed in many types of cancer.70, 71, 179, 180 Additionally, they activate the non-canonical NF-κB pathway through the accumulation of NIK, which is normally degraded by cIAP1.181, 182 This results in an upregulation of NF-κB target genes, including TNFα.