Adenosine receptor signaling resulted in either a pro-, or anti-inflammatory T-cell response during autoimmune uveitis depending on the phase of the disease [66], and one might imagine that the effect of EAD signaling may differ with phase of pneumococcal infection, providing a rationale for the lack of discernable effect of CD73 inhibition or ablation soon after I.T. inoculation, but a dramatic effect on the resolution of pulmonary inflammation later in infection. This evidence concerns the gene NT5E and autoimmune uveitis.