To determine if CD73 inhibition resulted in enhanced bacteremia in a mouse strain more resistant to S. pneumoniae infection [36], we I.T. challenged either mock-treated or CD73-inhibited BALB/c mice and found that CD73 inhibition was associated with a 100- to 1000-fold increase in bacteremia after day 3 post-infection (S3 Fig). Here, NT5E is linked to infection.