Stroke occurred in 4.2% of patients and the risk factors statistically significantwere: carotid stenosis of 70% or more (P=0.03; OR 5.07; IC 95%:1.35 to 19.02), diabetes on insulin (P=0.04; OR 2.61; IC 95%:1.10 to 6.21) and peripheral arteriopathy (P=0.03; OR 2.61; 95%CI: 1.08 to 6.28). This evidence concerns the gene INS and Stroke.