[16–18] In addition, elevated LMR was found to be an independent prognostic factor in patents with early-stage lung cancer after complete resection[19] and in patients with advanced-stage lung cancer who were undergoing platinum-based chemotherapies.[20] However, to the best of our knowledge, the prognostic significance of baseline and trend of LMR in EGFR-mutant NSCLC patients receiving first-line EGFR-TKIs has not been established. This evidence concerns the gene EGFR and lung carcinoma.