Because lymphocytes play an important role in tumor eradication[11] and macrophages are associated with tumor progression[12, 13], we presumed that patients with higher lymphocyte-to-monocyte ratio (LMR) might have better prognosis in EGFR-mutant NSCLC patients receiving first-line EGFR-TKIs. This evidence concerns the gene EGFR and non-small cell lung carcinoma.