Both AXL and SOCS3 were up-regulated approximately 2 fold in JFH1 infected cells (minimum 2 passages, 1 week post infection, 90% infectivity), but were surprisingly down-regulated in a stable cell line of Huh-7s harbouring a genotype 2a SGR [19] (Fig 1A). The gene discussed is SOCS3; the disease is infection.