TGIF2 and neoplasm: Since osteoclast activation is implicated in bone remodeling and growth of PCa cells in the bone [52, 53], inhibition of Tgif2 and other miR-34a targets in the microenvironment may explain the more profound effects on tumor growth in the bone than were observed subcutaneously, and demonstrate the importance of targeting both the tumor cell and the tumor microenvironment.