The concentration of MMP-12 in WF from breast cancer patients with luminal subtypes tended to be higher than that with HER2 overexpression and basal subtype (luminal A 703.41 pg/ml, luminal B 789.91 pg/ml, HER2 overexpression 436.47 pg/ml and basal 344.45 pg/ml, P = 0.013). The gene discussed is ERBB2; the disease is breast carcinoma.