Furthermore, with the prolongation of postoperative period, the concentrations of IL-1β, IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, IL-33, IFNγ and CD40L significantly decreased in the WF samples from breast cancer patients without NAC, as shown in Table 1. The gene discussed is IL31; the disease is breast carcinoma.