Furthermore, TNFα increased proliferation of human breast cancer cell line T47D through the intracellular signaling p42/p44 MAPK, JNK, PI3-K/Akt pathways and NF-kappa B transcriptional activation trigged by TNFα/TNFR1, TNFR 2 pathways [42]. This evidence concerns the gene AKT1 and breast cancer.