To investigate whether the level of IL-6 expression affects the apoptotic cell death in NSCLC cells following cisplatin treatment, A549IL-6si/sc and H157IL-6si/sc cells were treated with cisplatin for 48 hours and the apoptotic cell death was analyzed using the AnnexinV-based flow cytometric method. The gene discussed is ANXA5; the disease is non-small cell lung carcinoma.