Moreover, miR-126expression was markedly lower in the HF-AF group compared with the AF and HF groups.The 3 patient groups had higher N-terminal prohormone brain natriuretic peptide(NT-proBNP) levels, lower left ventricular ejection fraction (LVEF), larger leftatrial diameter, and higher cardiothoracic ratio compared with controls. This evidence concerns the gene NPPB and hydrops fetalis.