Moreover, circulating miR-126 is downregulated in acute myocardialinfarction and may have the potential for use as a novel biomarker for clinicaldiagnosis of acute myocardial infarction (21).Furthermore, plasma miR-126 levels are upregulated in HF patients, and miR-126 levelsare negatively correlated with B-type natriuretic peptide (BNP) serum levels (22,23).Interestingly, miR-126 is also downregulated in AF patients compared with healthycontrols, and may have an effect on diastolic dysfunction in AF, thus suggesting a rolefor miR-126 in progression of AF (11). This evidence concerns the gene NPPB and atrial fibrillation.