APLP2 and myopia: Visual form deprivation induced -1.2 ± 0.6 D of myopia (p = 3.0 × 10−2) in Aplp2-/- mice compared to -5.7 ± 1.1 D (p < 1.0 × 10−4) in Aplp2+/- heterozygotes and -11.0 ± 1.7 D (p < 1.0 × 10−4) in wild-type littermates, indicating that lack of Aplp2 expression has a dose-dependent inhibitory effect on susceptibility to environmentally induced myopia (F(2, 33) = 191.0, p < 1.0 × 10−4) (Fig 4B), thus confirming gene-environment interaction between APLP2 and visual experience identified by human studies.