Univariate analysis revealed that negative staining of ER (P = 0.007, odds ratio (OR) = 3.49), nNHERF1 (P = 0.039, OR = 4.41), HIF-1α (P = 0.032, OR = 2.78) and BRCA1 (P = 0.035, OR = 2.56) and positive cBRIT1 (P = 0.02, OR = 3.11) expression were significantly associated with large tumor size. The gene discussed is BRCA1; the disease is neoplasm.