BRCA1 and breast neoplasm: Using IHC on tissue microarrays (TMAs), we have focused on familial breast tumors in order to analyze the expression of different biomarkers involved in some pathways: progression (NHERF1, TWIST1, Claudin 1), DNA repair mechanisms (BRCT-repeat inhibitor of hTERT expression (BRIT1), SWItch 5 (SWI5), BRCA1 and PARP1), angiogenesis (vascular endothelial growth factor receptor 1 (VEGFR1), VEGF, HIF-1α and MVD), and breast staminal cell markers (CD44 and CD24).