BRCA1 and breast neoplasm: We have previously studied different angiogenic markers such as vascular endothelial growth factor (VEGF), hypoxia inducible factor-1 alpha (HIF-1α) and microvessel density (MVD) in familial BC and we suggested that angiogenesis plays a crucial role in BRCA1/2 carrier BC, supporting the aggressive nature of these tumors and assuming the possible use of novel combination therapy in this subgroup of breast tumor patients [13].