Some studies have also been carried out in order to characterize familial BC that are associated with BRCA1/2 germline mutations, through the evaluation of a panel of different immunohistochemical markers: they showed that BRCA1 and BRCA2 tumors can be differentiated because they have a specific immunohistochemical profile with respect to hormonal receptors, cell cycle, apoptosis and basal cell markers [14–16]. This evidence concerns the gene BRCA2 and breast cancer.