In particular, the immunoprofile characterized by the low expression of ER, PR, BRCA1, nNHERF1 and HIF-1α and the higher expression of MIB1, cNHERF1, cBRIT1, VEGF and VEGFR1 identified familial BC patients with a more aggressive immunophenotype as discussed above. The gene discussed is ESR1; the disease is breast cancer.