To explore the mechanisms underlying the antitumor activity of SFN, we tested the effect of SFN on the activities of PI3K/Akt, MAPK/Erk, MAPK/JNK and MAPK/p38 pathways, which play an important role in cell proliferation, metastasis and survival in thyroid cancer [3]. The gene discussed is MAPK8; the disease is thyroid cancer.