CCDC134 and neoplasm: The abnormal expression of the coiled-coil domain containing proteins has a direct link with the phenotype of tumor cell migration, invasion and metastasis, for example CCDC134 is down-regulated in gastric cancer and its silencing promotes the migration and invasion of both the normal gastric epithelial cell line GES-1 and gastric cancer cell line AGS via the MAPK pathway [10].