HGPS is caused by an autosomal dominant C to T nucleotide substitution at position 1824 (G608G) in LMNA, which activates a cryptic splice site and results in a truncated and constitutively farnesylated version of lamin A called progerin (De Sandre-Giovannoli et al., 2003; Eriksson et al., 2003). This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.