We thus found NPFs in several enhancer-binding proteins (Figure 5A), notably in RUNX and Osa/ARID1 (the DNA-binding subunit of SWI/SNF chromatin remodeling complexes; Wu and Roberts, 2013), and also in MACC1 (metastasis-associated in colon cancer 1) whose molecular function is unknown (Stein et al., 2009). This evidence concerns the gene MACC1 and colonic neoplasm.