AGT and hypertensive disorder: Taken together with previous mechanistic functional enzymatic studies that have shown that the oxidized form of angiotensinogen may predispose to hypertension by generating angiotensin with greater efficiency compared to the reduced form of angiotensinogen [10], our study supports the notion that dysregulation of the redox status of angiotensinogen is an important contributor to the hypertension associated with pre-eclampsia, and that the measurement of the redox form of angiotensinogen may serve as a useful biomarker for predicting the development of pre-eclampsia in pregnant individuals.