Because adjuncts to stem the pro-tumor effects of combination HRT are needed, in the present study we examined the therapeutic ability of the naturally occurring non-toxic flavonoid LU to suppress the growth of and expression of angiogenesis markers in progestin-dependent human breast cancer cell xenograft tumors in vivo, as well as it ability to suppress VEGF induction and the stem cell-like phenotype of breast cancer cells in vitro. Here, VEGFA is linked to neoplasm.