ALK and non-small cell lung carcinoma: Alterations in the ALK gene are known to play role in genesis and biology of many tumors including anaplastic large cell lymphoma, neuroblastoma, inflammatory myofibroblastic tumors, diffuse large B cell lymphoma, renal carcinoma, serous carcinoma of the ovary, esophageal squamous cell carcinoma, colon carcinoma and more recently non-small cell lung carcinoma.