PDK1 and breast cancer: Robertson et al. exclusively studied inflammatory breast cancers using Reverse Phase Protein Microarray analysis, a pathway activation mapping technique, and reported activation of multiple members of the receptor tyrosine kinase ALK signaling network (JAK1/STAT3, AKT, mTOR, PDK-1 and AMP kinase β) in inflammatory breast cancer cell lines, at levels similar to those in ALK rearranged non-small cell lung cancers.