Jia et al. (2014) reported that increased ALK copy number gains in hepatocellular carcinoma are associated with a decreased 3-year overall survival (18.2 vs 63.6 %; p = 0.021) and 3-year progression free survival (18.2 vs 46.9 %; p = 0.019) as compared to those without ALK copy number alterations. This evidence concerns the gene ALK and hepatocellular carcinoma.