Of these 82 cases, four (5 %) demonstrated HCNGs of ALK (range 6–13 % of tumor cells) and include 1 ER−/PR−/HER2−, 2 ER+/PR−/HER2− and 1 HER2 only positive (ER−/PR−/HER2+) case. This evidence concerns the gene ESR1 and neoplasm.