The link between IRAK-1 expression and obesity-associated meta-inflammation is also supported by the relationship of IRAK-1 or IRAK-2 with other inflammatory conditions such as lung cancer [44], systemic lupus erythematosus [45], Vogt-Koyanagi-Harada (VKH) disease [46], and Alzheimer’s disease [47]. This evidence concerns the gene IRAK1 and early-onset autosomal dominant Alzheimer disease.