CTNNB1 and medulloblastoma: DDX3 dependency seemed to be greater in the presence of wild-type APC-status and activating mutations in CTNNB1. This finding is in line with the co-occurrence of DDX3X and CTNNB1 mutations in medulloblastomas [7–9] and provides a potential explanation for the fact that HT29, which harbors a mutation in APC, does not show a clear G1 arrest upon DDX3 knockdown.