High SPHK1 expression was associated with larger tumor size (p < 0.001), deeper invasion depth (p < 0.001), presence of lymph node metastasis (p = 0.029), higher FIGO stage (p = 0.029), presence of lymphovascular invasion (p = 0.045), and higher preoperative squamous cell carcinoma (SCC) antigen level (p = 0.009), indicating that SPHK1 expression is associated with aggressive oncogenic behavior of cervical cancer. This evidence concerns the gene SERPINB3 and neoplasm.