This finding is consistent with a recent report that dendropanoxide (DP), which comes from the leaves and stem of Dendropanax morbiferus H.Lév, induced a time-dependent accumulation of Atg7, Beclin1, and LC3-II in osteosarcoma cells, and that treatment with U0126, 3-MA, and wortmannin significantly decreased DP-induced autophagy that was accompanied by increased apoptosis [53]. This evidence concerns the gene BECN1 and osteosarcoma.