In this study, we found higher levels of Th2 and Treg cytokines (including FOXP3) in lesions from patients with either IgG4-RD or ocular IgG4-associated MZL than in samples from patients with ocular adnexal IgG4-negative MZL. This evidence concerns the gene FOXP3 and immunoglobulin G4-related sclerosing disease.