In addition, through analysis of the more severe mdx:utr double knock out model of DMD, an even lower proportion of Cx43 expression was observed at intercalated discs (46% ± 5% MEAN ± SEM, n = 5), demonstrating that while initial Cx43 remodeling occurs before overt cardiac pathology is present, it increases as signs of dilated cardiomyopathy and fibrosis appear (Fig. 1a,b). The gene discussed is GJA1; the disease is dilated cardiomyopathy.