Univariate analysis showed that the following factors had a significant impact on OS of HCC patients: higher tumor HNF-1B expression (P = 0.001), higher tumor K19 expression (P = 0.013), higher tumor K7 expression (P < 0.001), larger tumor size (P = 0.012), higher TNM stage (P = 0.015), and lymphovascular invasion (P = 0.008) (Table 3). The gene discussed is HNF1B; the disease is hepatocellular carcinoma.