Multivariate analysis indicated that higher tumor HNF-1B expression (hazard ratio (HR): 1.637, 95% CI: 1.093,2.450, P = 0.017), higher tumor K7 expression (HR: 1.799, 95% CI: 1.220–2.654, P = 0.003), larger tumor size (HR:1.461, 95% CI: 1.012,2.108, P = 0.043), multiple tumor number (HR: 1.708, 95% CI: 1.004–2.904, P = 0.048), and lymphovascular invasion (HR: 1.633, 95% CI: 1.101,2.423, P = 0.015) were independent prognostic factors for OS (Table 3). This evidence concerns the gene HNF1B and neoplasm.