Based on the preliminary observations from microarray studies and the relation of DHRS7 to SDRs involved in PCa, we investigated the role of DHRS7 in PCa, taking advantage of a combination of human data obtained on a large cohort (n = 348) of samples on tissue microarrays [20,21] and in vitro experiments comprising modulation of DHRS7 expression by knockdown. Here, DHRS7 is linked to posterior cortical atrophy.