Since DHRS7 expression decreases significantly as the tumor grade increases, we investigated the functional effects of silencing DHRS7 expression in prostate cell lines endogenously expressing DHRS7 at different amounts, as determined by real-time PCR, western blotting and immunovisualization, namely LNCaP (high), PC3 (moderate), and BPH1 (low) (Fig.2). This evidence concerns the gene DHRS7 and neoplasm.