Recently, we found for the first time that ATO can downregulate the level of Mcl-1 in MCL cells 26, which suggested that combined use of ATO and BTZ may not only increase the proapoptotic protein Noxa but also reduce the antiapoptotic protein Mcl-1, and thereby play a synergistic effect on induction of apoptosis in MCL cells. The gene discussed is PMAIP1; the disease is mantle cell lymphoma.