We found that ATO could inhibit the proliferation of MCL cell lines Jeko-1 and Granta-519 cooperatively with BTZ; combination of two drugs could also cooperatively induce the apoptosis of MCL cell lines, and the proapoptotic effect of ATO combined with low-dose BTZ was apparently stronger than that of relative higher dose of BTZ. Here, CASC3 is linked to mantle cell lymphoma.