Of note, the cooperative effect of 2 μmol/L ATO and 7.5 nmol/L BTZ on apoptotic induction of MCL cells was significantly higher than 10 nmol/L BTZ monotherapy (P < 0.05); while in the nontumor cells (CD45+CD19− cells), the apoptotic induction effect of two-drug combination therapy was weaker (Fig.5A). The gene discussed is CD19; the disease is mantle cell lymphoma.